Endocrine Abstracts

Growth hormone (GH) responsive cells are extensively distributed in the brain, including in neurons of the arcuate nucleus (ARH) and ventromedial nucleus (VMH) of the hypothalamus, areas that control food intake, energy expenditure and blood glucose levels. However, the functional role of central GH signaling for energy and glucose homeostasis has not been unveiled yet. We generated mice lacking GH receptor (GHR) in multiple neuronal populations to investigate whether central ...

Introduction: The availability of the body’s most abundant amino acid, glutamine is compromised in obesity-associated diabetes. This may impair glucose metabolism by increasing hepatic insulin resistance, oxidative stress and the development of nonalcoholic fatty liver disease (NAFLD).Objective: Evaluate the effects of free and dipeptide (DIP, L-alanyl-L-glutamine) forms of L-glutamine on glucose metaboli...